Modulation of Early Mitotic Inhibitor 1 (EMI1) Depletion on the Sensitivity of PARP Inhibitors in BRCA1 Mutated Triple-Negative Breast Cancer Cells
J. D. Parvin, D. Moustafa, M. R. A. Elwahed, H. H. Elsaid
This study shows that EMI1 depletion increases resistance to PARP inhibitors and other DNA repair/cell cycle drugs in BRCA1-mutated TNBC cells, with potential for CHK1 inhibitor combination therapy.
bioRxiv · Jun 9, 2020Cancer Biology