Immunogenicity of SARS-CoV-2 trimetric spike protein associated to Poly(I:C) plus Alum
J. d. Santos, L. F. Cruz, A. M. d. Fonseca-Martins, D. O. Maciel, G. G. Perez, V. A. Roncaglia-Pereira, C. H. Dumard, F. H. Guedes da Silva, A. C. V. dos Santos, M. S. Leandro, J. R. M. Ferreira, K. G. Pinto, L. Conde, D. A. S. Rodrigues, M. V. M. Silva, , H. L. de Matos Guedes
This study evaluates a vaccine strategy using Alum and Poly(I:C) adjuvants with SARS-CoV-2 spike protein, showing enhanced antibody and T-cell responses and reduced lung inflammation.
bioRxiv · Oct 5, 2021 · PreprintImmunology