Allosteric Receptor Modulation uncovers an FFAR2 antagonist as a positive orthosteric modulator/agonist in disguise
S. Lind, D. Olofsson Hoffman, H. Forsman, C. Dahlgren
The paper reveals that GLPG0974, previously classified as an FFAR2 antagonist, also acts as a positive orthosteric modulator/agonist by enhancing neutrophil activation and downstream signaling when combined with co-agonistic PAMs.
bioRxiv · May 19, 2021Pharmacology & Toxicology