Antagonists of the stress and opioid systems restore the functional connectivity of the prefrontal cortex during alcohol withdrawal through divergent mechanisms.
Lieselot L. G. Carrette, Aline Valéria Sousa Santos, Molly Brennan, D. Othman, Andrés Collazo, Olivier George
This study shows that CRF1 antagonist R121919 and naltrexone restore prefrontal cortex functional connectivity during alcohol withdrawal through distinct mechanisms involving modularity and connectivity changes.
bioRxiv · Sep 30, 2023 · PreprintNeuroscience