Olivier George

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

The paper replicates the association between St6galnac1 and Paraprevotella abundance in stool samples from non-fasted HS rats, confirming the association across different experimental conditions.

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

This study shows that higher addiction-like severity in rats predicts prolonged oxycodone withdrawal-induced allodynia, with stronger associations between self-administration behaviors and pain sensitivity.

The paper identifies incentive salience as the driver of cocaine self-administration escalation in rats, showing individual differences in pre-lever activity predict long-term intake.

This study identifies sex-specific transcriptional changes in the SCN of rats during oxycodone withdrawal and abstinence, linking these changes to addiction-related behaviors.

This study finds that irregular estrous cycles in HS rats are associated with severe cocaine addiction-like behaviors, but estrous phase itself does not influence cocaine self-administration.

The paper shows that escalation of cocaine intake, progressive ratio responding, and continued use despite adverse consequences are highly correlated in rats, with sex differences in addiction-like behaviors.

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

The paper describes a scalable, low-cost video recording system for simultaneous animal behavior monitoring in operant chambers, achieving high throughput and fidelity with minimal storage.

This study shows that CRF1 antagonist R121919 and naltrexone restore prefrontal cortex functional connectivity during alcohol withdrawal through distinct mechanisms involving modularity and connectivity changes.

This study shows that gut microbiome depletion increases cocaine-seeking behavior in rats, which can be reversed by replenishing short-chain fatty acids.

The paper investigates how cholinergic systems contribute to changes in brain functional connectivity during nicotine withdrawal in male mice, identifying two distinct long-range cholinergic networks and associated genes.

This study compares voluntary and forced ethanol exposure in rats, finding similar drinking escalation and blood alcohol levels but distinct brain region activation during withdrawal.

The paper identifies cell type-specific gene regulatory changes in the amygdala of rats with varying cocaine addiction-like behaviors, linking them to energy metabolism, GABAergic inhibition, and chromatin accessibility.

The paper identifies individual differences in oxycodone addiction-like behaviors in HS rats to uncover genetic factors contributing to vulnerability and resilience.

The paper identifies microbiome and metabolic vulnerabilities linked to oxycodone self-administration escalation and shows SCFAs have a causal role in addiction-like behaviors.

The paper tests individual differences in response to methadone, buprenorphine, and naltrexone in rats with opioid use disorder, finding varying efficacy based on addiction severity.

The paper investigates how drug exposure alters gene regulatory networks in the brain using multi-omics approaches, identifying enhancer repression and transcription factor involvement in addiction-related behaviors.

This study investigates the effects of deep brain stimulation (DBS) on cocaine self-administration in cocaine-dependent rats and finds it increases cocaine intake but raises GluR1 levels in the central nucleus of the amygdala.

The paper uses single-cell whole-brain imaging to analyze how psychostimulant withdrawal alters brain functional architecture, finding reduced modularity as a common feature across drugs.

The paper examines individual differences in addiction-like behaviors and cocaine versus food choice in Heterogeneous Stock rats, finding that high addiction score rats show increased cocaine preference after recent cocaine use.

This study links gut microbiota composition to cocaine behavior in rats, showing that baseline microbial profiles predict addiction vulnerability.

Vaping nicotine-containing e-cigarettes causes addiction-like behaviors and cardiopulmonary issues in rats, which are reduced by varenicline.

The paper validates the three-stage theory of addiction using single-cell whole-brain imaging in a mouse model, showing abstinence reduces brain modularity and clusters regions corresponding to each stage.

The paper identifies a subset of brainstem neurons that control urethral sphincter relaxation and scent marking behavior in mice.

This study shows that inhibiting glyoxalase 1 with pBBG reduces alcohol self-administration in both dependent and nondependent rats, with greater effect in dependent animals.

This study shows that dynorphin in the paraventricular nucleus of the thalamus counteracts orexin's effect on cocaine-seeking behavior by reducing glutamate release.

This study examines irritability-like behavior in ethanol-dependent rats and shows that CRF1 receptor antagonism reduces this behavior during abstinence.

Cebranopadol reduces cocaine intake escalation and reinstatement in rats but induces conditioned place preference.