Lieselot L. G. Carrette

This study performs a GWAS on cocaine self-administration in rats, identifying six genome-wide significant loci, including one linked to carboxylesterase genes involved in cocaine metabolism.

This study shows that higher addiction-like severity in rats predicts prolonged oxycodone withdrawal-induced allodynia, with stronger associations between self-administration behaviors and pain sensitivity.

The paper identifies incentive salience as the driver of cocaine self-administration escalation in rats, showing individual differences in pre-lever activity predict long-term intake.

This study finds that irregular estrous cycles in HS rats are associated with severe cocaine addiction-like behaviors, but estrous phase itself does not influence cocaine self-administration.

The paper shows that escalation of cocaine intake, progressive ratio responding, and continued use despite adverse consequences are highly correlated in rats, with sex differences in addiction-like behaviors.

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

This study shows that CRF1 antagonist R121919 and naltrexone restore prefrontal cortex functional connectivity during alcohol withdrawal through distinct mechanisms involving modularity and connectivity changes.

The paper investigates how cholinergic systems contribute to changes in brain functional connectivity during nicotine withdrawal in male mice, identifying two distinct long-range cholinergic networks and associated genes.

The paper identifies cell type-specific gene regulatory changes in the amygdala of rats with varying cocaine addiction-like behaviors, linking them to energy metabolism, GABAergic inhibition, and chromatin accessibility.

The paper identifies individual differences in oxycodone addiction-like behaviors in HS rats to uncover genetic factors contributing to vulnerability and resilience.

The paper identifies microbiome and metabolic vulnerabilities linked to oxycodone self-administration escalation and shows SCFAs have a causal role in addiction-like behaviors.

The paper tests individual differences in response to methadone, buprenorphine, and naltrexone in rats with opioid use disorder, finding varying efficacy based on addiction severity.

The paper investigates how drug exposure alters gene regulatory networks in the brain using multi-omics approaches, identifying enhancer repression and transcription factor involvement in addiction-related behaviors.

The paper examines individual differences in addiction-like behaviors and cocaine versus food choice in Heterogeneous Stock rats, finding that high addiction score rats show increased cocaine preference after recent cocaine use.

Vaping nicotine-containing e-cigarettes causes addiction-like behaviors and cardiopulmonary issues in rats, which are reduced by varenicline.