The HIV-1 Vpu transmembrane domain topology and formation of a hydrophobic interface with BST-2 are critical for Vpu-mediated BST-2 downregulation
N. Khan, S. Padhi, P. Patel, D. P. U., S. Jameel
This study shows that the topology and hydrophobic interface of HIV-1 Vpu are critical for BST-2 downregulation, with shape and interface availability being more important than amino acid conservation.
bioRxiv · Jun 28, 2020 · PreprintCell Biology