Cervical gene delivery of the antimicrobial peptide, Human β-defensin (HBD)-3, in a mouse model of ascending infection-related preterm birth
N. Suff, R. Karda, J. Antinao Diaz, N. Joanne, B. Julian, D. Perocheau, P. W. Taylor, D. Alber, S. M. K. Buckley, M. Bajaj-Elliott, S. N. Waddington, D. Peebles
This study shows that delivering HBD3 via AAV8 vector reduces bacterial ascent and improves outcomes in a mouse model of ascending infection-related preterm birth.
bioRxiv · May 20, 2019Immunology