Impact of different mutations on Kelch13 protein levels, ART resistance and fitness cost in Plasmodium falciparum parasites
H. M. Behrens, S. Schmidt, D. Peigney, R. Sabitzki, I. Henshall, J. May, O. Maïga-Ascofare, T. Spielmann
This study examines how mutations in K13 and related genes affect ART resistance, protein levels, and fitness cost in Plasmodium falciparum parasites, finding no benefit from double mutations but highlighting the fitness cost of ubp1R3138H.
bioRxiv · May 13, 2022 · PreprintMicrobiology