Opposing effects of T cell receptor signal strength on CD4 T cells responding to acute versus chronic viral infection
M. Künzli, P. Reuther, D. Pinschewer, C. G. King
This study shows that TCR signal strength promotes Th1 cells in acute infection but suppresses them in chronic infection, while supporting Tfh cells in chronic infection.
bioRxiv · Aug 6, 2020Immunology