Thymically-derived Foxp3+ regulatory T cells are the primary regulators of type 1 diabetes in the non-obese diabetic mouse model
D. R. Holohan, F. Van Gool, J. A. Bluestone
This study investigates the role of thymically-derived Foxp3+ regulatory T cells (tTregs) versus peripherally-derived (pTregs) in type 1 diabetes (T1D) using NOD mice, finding that pTregs are not the primary regulators of T1D.
bioRxiv · May 20, 2019Immunology