Author

F. Van Gool

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

J. A. Bluestone· 3 shared T. Roth· 2 shared A. Azouz· 1 shared A. M. R. Marson· 1 shared A. Marson· 1 shared B. Zhang· 1 shared C. Raffin· 1 shared D. Fang· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

J. A. Bluestone

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4 papers

Recent·Most cited

The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28

Y. Muller, D. Nguyen, L. M. R. Ferreira, P. Ho, C. Raffin, R. Beltran Valencia, Z. Congrave-Wilson, T. Roth, J. Eyquem, F. Van Gool, A. M. R. Marson, J. A. Wells, J. A. Bluestone, Q. Tang

This paper shows that CD28-TMD in CARs forms heterodimers with endogenous CD28, affecting T-cell responses and surface expression.

bioRxiv · Sep 18, 2020Bioengineering

CRISPR Screen in Regulatory T Cells Reveals Ubiquitination Modulators of Foxp3

J. T. Cortez, E. Montauti, E. Shifrut, Y. Zhang, O. Shaked, Y. Xu, T. Roth, D. Simeonov, Y. Zhang, S. Chen, Z. Li, I. A. Vogel, G. Y. Prator, B. Zhang, Y. Lee, , D. Fang

This study uses a CRISPR screen in mouse Tregs to identify genes regulating Foxp3 expression, finding Usp22 and Atxn7l3 as stabilizers and Rnf20 as a destabilizer.

bioRxiv · Feb 26, 2020 · PreprintImmunology

Multiple environmental signaling pathways control the differentiation of RORγt-expressing regulatory T cells

H. Hussein, S. Denanglaire, F. Van Gool, A. Azouz, Y. Ajouaou, H. El-Khatib, G. Oldenhove, O. Leo, F. Andris

This study identifies multiple environmental signaling pathways that regulate RORγt+ Treg differentiation, showing both positive and negative signals interact with c-Maf.

bioRxiv · Oct 8, 2019Immunology

Thymically-derived Foxp3+ regulatory T cells are the primary regulators of type 1 diabetes in the non-obese diabetic mouse model

D. R. Holohan, F. Van Gool, J. A. Bluestone

This study investigates the role of thymically-derived Foxp3+ regulatory T cells (tTregs) versus peripherally-derived (pTregs) in type 1 diabetes (T1D) using NOD mice, finding that pTregs are not the primary regulators of T1D.

bioRxiv · May 20, 2019Immunology