Author

D. R. Silveira

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

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Assay:ATAC-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

A. K. Gandhi· 1 shared A. Smith· 1 shared B. Usukhbayar· 1 shared C.-X. Song· 1 shared L. Quek· 1 shared M. Hasan· 1 shared M. Metzner· 1 shared O. Yavorska· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. K. Gandhi

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1 paper

Recent·Most cited

Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia.

D. R. Silveira, P. Chatzikyriakou, P. Casares Alaez, S. Mackie, R. Hulks, O. Yavorska, P. Siejka-Zielinska, A. Smith, M. Metzner, B. Usukhbayar, V. Penard-Lacronique, C.-X. Song, A. K. Gandhi, P. Vyas, T. Milne, , L. Quek

This study shows that IDH2 mutations in AML block differentiation by altering H3K27 methylation, and that Enasidenib can reverse this block by modulating chromatin states.

bioRxiv · Aug 24, 2023 · PreprintCancer Biology