Author

M. Metzner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:scRNA-seq· 3 Approach:statistical model· 3 Assay:ATAC-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2

Frequent Co-Authors

P. Vyas· 4 shared B. Usukhbayar· 3 shared N. A. Jakobsen· 3 shared A. H. Taylor· 2 shared A. J. Carr· 2 shared B. Watkins· 2 shared C. Nerlov· 2 shared D. Beazley· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

P. Vyas

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Author profile →

4 papers

Recent·Most cited

Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

N. A. Jakobsen, S. Turkalj, A. G. X. Zeng, B. Stoilova, M. Metzner, M. S. Nagree, S. Shah, R. Moore, B. Usukhbayar, M. A. Salazar, G.-A. Gafencu, A. Kennedy, S. Newman, B. J. L. Kendrick, A. H. Taylor, , P. Vyas

This study identifies how DNMT3A and TET2 mutations in hematopoietic stem cells confer a selective advantage by reducing inflammation and aging effects.

bioRxiv · Sep 12, 2023 · PreprintCancer Biology

Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia.

D. R. Silveira, P. Chatzikyriakou, P. Casares Alaez, S. Mackie, R. Hulks, O. Yavorska, P. Siejka-Zielinska, A. Smith, M. Metzner, B. Usukhbayar, V. Penard-Lacronique, C.-X. Song, A. K. Gandhi, P. Vyas, T. Milne, , L. Quek

This study shows that IDH2 mutations in AML block differentiation by altering H3K27 methylation, and that Enasidenib can reverse this block by modulating chromatin states.

bioRxiv · Aug 24, 2023 · PreprintCancer Biology

Identification and Age-dependent Increase of Platelet Biased Human Hematopoietic Stem Cells

M. Aksoz, G.-A. Gafencu, B. S. Stoilova, M. Buono, Y. Meng, N. A. Jakobsen, M. Metzner, S.-A. Clark, R. Beveridge, S. Thongjuea, P. Vyas, C. Nerlov

The paper identifies platelet-biased human hematopoietic stem cells (HSCs) and shows their proportion and transcriptional platelet priming increase with age.

bioRxiv · Jan 14, 2022 · PreprintCell Biology

Detecting and quantifying clonal selection in somatic stem cells

V. Korber, N. Ansari-Pour, N. A. Jakobsen, R. Moore, N. Claudino, M. Metzner, F. Horsch, B. Usukhbayar, M. A. Salazar, S. Newman, B. J. Kendrick, A. H. Taylor, R. Afinowi-Luitz, R. Gundle, B. Watkins, , T. Hofer

This study introduces SCIFER, a method to detect and quantify clonal selection in somatic stem cells, revealing accelerated stem cell division in clonal hematopoiesis.

bioRxiv · Dec 15, 2021Cancer Biology