D. R. Valenzano

Age-dependent decline in sperm quality and function in a naturally short-lived vertebrate

This study shows that turquoise killifish males experience reproductive aging despite being short-lived, with declining sperm quality and reduced embryo survival as they age.

Assessing Age-Related Decline in Anti-Bacterial Immune Responses Using an Ex-vivo Assay in African Turquoise Killifish (Nothobranchius furzeri)

This study develops an ex-vivo assay to assess age-related decline in anti-bacterial immune responses in African turquoise killifish, finding reduced bacterial growth inhibition in aged fish.

Spontaneous onset of cellular markers of inflammation and genome instability during aging in the immune niche of the naturally short-lived turquoise killifish (Nothobranchius furzeri)

This study identifies age-related inflammation and genome instability in the immune niche of turquoise killifish using single-cell RNA sequencing and proteomics.

Population size shapes the evolution of lifespan

This study examines how population size affects lifespan evolution under mutation accumulation and antagonistic pleiotropy, finding that larger populations reduce mortality and can extend lifespan.

Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish

This study examines age-related loss of antibody diversity in turquoise killifish, showing rapid decline in whole-body and intestinal repertoires with age.

Genomics of a killifish from the Seychelles islands supports transoceanic island colonization and reveals relaxed selection of developmental genes

The study uses genomic data from Seychelles killifish to support trans-oceanic colonization and identifies relaxed selection on developmental genes.

Intra-Species Differences in Population Size shape Life History and Genome Evolution

This study investigates how population size differences among turquoise killifish populations affect lifespan and genome evolution, finding that small populations accumulate deleterious mutations linked to short lifespan.

Extreme genomic volatility characterises the evolution of the immunoglobulin heavy chain locus in teleost fishes

This study examines the genomic structure and evolution of the immunoglobulin heavy chain locus in teleost fishes, revealing extreme volatility through duplication and deletion events in the IGHZ gene.

AEGIS: An In Silico Tool to Model Genome Evolution in Age-Structured Populations

AEGIS models genome evolution in age-structured populations, showing ageing-like phenotypes emerge in stable environments and sexual reproduction enhances beneficial mutation accumulation.