Author

W. J. Bradshaw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:zebrafish· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CITE-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. R. Valenzano· 3 shared A. J. Birkett· 1 shared A. J. R. Cooper· 1 shared A. M. Lias· 1 shared A. M. Minassian· 1 shared A. Placzek· 1 shared A. R. Noe· 1 shared A. Sajina· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

D. R. Valenzano

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

J. R. Barrett, D. Pipini, N. D. Wright, A. J. R. Cooper, G. Gorini, D. Quinkert, A. M. Lias, H. Davies, C. Rigby, M. Aleshnick, B. G. Williams, W. J. Bradshaw, N. G. Paterson, T. Martinson, P. Kirtley, , S. J. Draper

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

Cell · Sep 1, 2024Peer-reviewedImmunology

Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2

W. J. Bradshaw, E. C. Kennedy, T. Moreira, L. A. Smith, R. Chalk, V. L. Katis, J. L. Benesch, P. E. Brennan, E. J. Murphy, O. Gileadi

The paper determines structures of SHIP1 and SHIP2 phosphatase and C2 domains, showing the C2 domain modulates phosphatase activity more in SHIP2 than SHIP1, providing insights for drug development.

bioRxiv · Jul 31, 2023Biochemistry

Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish

W. J. Bradshaw, M. Poeschla, A. Placzek, S. Kean, D. R. Valenzano

This study examines age-related loss of antibody diversity in turquoise killifish, showing rapid decline in whole-body and intestinal repertoires with age.

bioRxiv · Aug 21, 2020Immunology

Extreme genomic volatility characterises the evolution of the immunoglobulin heavy chain locus in teleost fishes

W. J. Bradshaw, D. R. Valenzano

This study examines the genomic structure and evolution of the immunoglobulin heavy chain locus in teleost fishes, revealing extreme volatility through duplication and deletion events in the IGHZ gene.

bioRxiv · Sep 3, 2019Immunology

AEGIS: An In Silico Tool to Model Genome Evolution in Age-Structured Populations

W. J. Bradshaw, A. Sajina, D. R. Valenzano

AEGIS models genome evolution in age-structured populations, showing ageing-like phenotypes emerge in stable environments and sexual reproduction enhances beneficial mutation accumulation.

bioRxiv · May 23, 2019 · PreprintEvolutionary Biology