Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cell populations
T. Dismuke, D. S. Malawsky, H. Liu, J. Brenman, B. Dasgupta, A. Tikunov, T. R. Gershon
This study shows that inactivating AMPK in medulloblastoma models slows tumor progression by reducing tumor stem cells and mTORC1 activity.
bioRxiv · Dec 9, 2021 · PreprintCancer Biology