Antigen-specific stimulation and expansion of CAR-T cells using membrane vesicles as target cell surrogates
V. M. Ukrainskaya, Y. P. Rubtsov, D. S. Pershin, N. A. Podoplelova, S. S. Terekhov, I. A. Yaroshevich, A. I. Sokolova, D. V. Bagrov, E. A. Kulakovskaya, V. O. Shipunova, S. M. Deyev, E. G. Maksimov, O. V. Markov, A. L. Oshchepkova, M. A. Zenkova, , R. A. Lerner
This paper develops a method using antigenic membrane vesicles to specifically stimulate and expand CAR-T cells, showing improved efficacy compared to existing protocols.
bioRxiv · Mar 18, 2021Immunology