Author

R. A. Lerner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

I. A. Wilson· 2 shared J. Xie· 2 shared N. C. Wu· 2 shared A. G. Gabibov· 1 shared A. Harding· 1 shared A. I. Sokolova· 1 shared A. J. Thompson· 1 shared A. L. Oshchepkova· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

I. A. Wilson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing

Z. Yang, G. Grande, Y. Hou, C. Wang, Y. Shi, J. Zak, J. H. Cho, D. Liu, J. Teijaro, R. A. Lerner, P. Wu

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.

bioRxiv · May 22, 2022 · PreprintCancer Biology

Antigen-specific stimulation and expansion of CAR-T cells using membrane vesicles as target cell surrogates

V. M. Ukrainskaya, Y. P. Rubtsov, D. S. Pershin, N. A. Podoplelova, S. S. Terekhov, I. A. Yaroshevich, A. I. Sokolova, D. V. Bagrov, E. A. Kulakovskaya, V. O. Shipunova, S. M. Deyev, E. G. Maksimov, O. V. Markov, A. L. Oshchepkova, M. A. Zenkova, , R. A. Lerner

This paper develops a method using antigenic membrane vesicles to specifically stimulate and expand CAR-T cells, showing improved efficacy compared to existing protocols.

bioRxiv · Mar 18, 2021Immunology

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago

M. Qiang, P. Ma, Y. Li, H. Liu, A. Harding, C. Min, L. Liu, M. Yuan, Q. Ji, P. Tao, X. Shi, Z. Li, F. Wang, Y. Zhang, N. C. Wu, , R. A. Lerner

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

bioRxiv · Nov 6, 2020 · PreprintMicrobiology

Influenza H3 and H1 hemagglutinins have different genetic barriers for resistance to broadly neutralizing stem antibodies

N. C. Wu, A. J. Thompson, J. M. Lee, W. Su, B. M. Arlian, J. Xie, R. A. Lerner, H.-L. Yen, J. D. Bloom, I. A. Wilson

The paper evaluates genetic barriers to resistance against broadly neutralizing antibodies targeting the stem region of influenza H3 and H1 hemagglutinins, finding H3 has lower resistance barriers.

bioRxiv · Dec 30, 2019 · PreprintMicrobiology