The RNA-binding site of poliovirus 3C protein doubles as a phosphoinositide-binding domain
D. Shengjuler, Y. M. Chan, S. Sun, I. M. Moustafa, Z.-L. Li, D. W. Gohara, M. Buck, P. S. Cremer, D. D. Boehr, C. E. Cameron
This study identifies a dual function in poliovirus 3C protein, showing it binds both RNA and phosphoinositides, with PIP binding mediated by residues also involved in RNA binding.
bioRxiv · Aug 4, 2017Biochemistry