DHA shortage causes the early degeneration of photoreceptors and RPE in mice with peroxisomal β-oxidation deficiency
D. Swinkels, S. Kocherlakota, Y. Das, A. D. Dane, E. J. M. Wever, F. M. Vaz, N. G. Bazan, P. P. Van Veldhoven, M. Baes
This study shows DHA supplementation rescues early retinal degeneration in Mfp2-/- mice by restoring retinal DHA levels and improving RPE function, but not long-term retinal integrity.
bioRxiv · Aug 9, 2023Cell Biology