Author

F. M. Vaz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:metabolomics· 5 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Organism:C. elegans· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

G. E. Janssens· 3 shared R. H. Houtkooper· 3 shared A. W. Gao· 2 shared H. L. Elfrink· 2 shared M. van Weeghel· 2 shared R. L. Smith· 2 shared A. C. Luyf· 1 shared A. D. Dane· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

G. E. Janssens

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6 papers

Recent·Most cited

DHA shortage causes the early degeneration of photoreceptors and RPE in mice with peroxisomal β-oxidation deficiency

D. Swinkels, S. Kocherlakota, Y. Das, A. D. Dane, E. J. M. Wever, F. M. Vaz, N. G. Bazan, P. P. Van Veldhoven, M. Baes

This study shows DHA supplementation rescues early retinal degeneration in Mfp2-/- mice by restoring retinal DHA levels and improving RPE function, but not long-term retinal integrity.

bioRxiv · Aug 9, 2023Cell Biology

Acyl-CoA dehydrogenase substrate promiscuity limits the potential for development of substrate reduction therapy in disorders of valine and isoleucine metabolism

S. M. Houten, T. Dodatko, W. Dwyer, H. Chen, B. Stauffer, R. J. DeVita, F. M. Vaz, C. Yu, J. Leandro

This study investigates whether inhibiting ACAD8 and SBCAD can reduce toxic metabolite accumulation in valine and isoleucine metabolism disorders, finding that MCPA inhibits multiple ACADs and partially rescues lipoylation defects in ECHS1-deficient cells.

bioRxiv · Nov 22, 2022Biochemistry

Work and oxygen consumption of isolated right ventricular papillary muscle in experimental pulmonary hypertension

W. J. van der Laarse, S. J. P. Bogaards, I. Schalij, A. Vonk Noordegraaf, F. M. Vaz, D. van Groen

This study investigates reduced mechanical efficiency in right ventricular myocardium of pulmonary hypertension by analyzing work, oxygen consumption, and mitochondrial parameters in MCT-PH rats.

bioRxiv · Dec 30, 2021Physiology

Reduced ech-6 Expression Attenuates Fat-induced Premature Aging in C. elegans

Y. J. Liu, A. W. Gao, R. L. Smith, G. E. Janssens, D. M. Panneman, A. Jongejan, M. van Weeghel, F. M. Vaz, M. J. Silvestrini, L. R. Lapierre, A. W. MacInnes, R. H. Houtkooper

This study shows that reducing ech-6 expression in C. elegans mitigates fat-induced premature aging, suggesting a role for ech-6 in metabolic flexibility and longevity.

bioRxiv · Nov 2, 2020 · PreprintCell Biology

Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

N. M. Held, R. Buijink, H. L. Elfrink, S. Kooijman, G. E. Janssens, F. M. Vaz, S. Michel, R. H. Houtkooper, M. Weeghel van

This study shows aging reduces lipid oscillations in adipose tissues, with BAT showing specific acyl chain length-dependent rhythms lost in older mice.

bioRxiv · Sep 4, 2020Biochemistry

Metabolomics and lipidomics in C. elegans using a single sample preparation

M. Molenaars, B. V. Schomakers, H. L. Elfrink, A. W. Gao, M. A. T. Vervaart, M. L. Pras-Raves, A. C. Luyf, R. L. Smith, M. G. Sterken, J. E. Kammenga, A. H. C. van Kampen, G. E. Janssens, F. M. Vaz, M. van Weeghel, R. H. Houtkooper

This paper introduces a single-sample preparation method for comprehensive metabolomics and lipidomics in C. elegans, enabling semi-quantitative analysis of over 100 polar metabolites and over 1000 apolar metabolites.

bioRxiv · Jul 6, 2020Biochemistry