CRISPR Screening in Tandem with Targeted mtDNA Damage Reveals WRNIP1 Essentiality
T. Sack, P. Dhavarasa, D. Szames, S. O'Brien, S. Angers, S. O. Kelley
The paper uses mtDNA-damaging agents and CRISPR screening to identify genes essential for mtDNA damage response, finding WRNIP1 essential for mtDNA repair and mitochondrial turnover.
bioRxiv · Oct 3, 2023Biochemistry