S. Angers

Systematic profiling of the acetyl lysine machinery reveals a role for MAPKAPK2 in bromodomain inhibitor resistance

This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.

Integrating in silico predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells

The paper identifies Perlecan as a factor that influences muscle stem cell re-quiescence, showing its age-related changes and therapeutic potential.

CRISPR Screening in Tandem with Targeted mtDNA Damage Reveals WRNIP1 Essentiality

The paper uses mtDNA-damaging agents and CRISPR screening to identify genes essential for mtDNA damage response, finding WRNIP1 essential for mtDNA repair and mitochondrial turnover.

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

SCF-FBXW7 regulates G2-M progression through control of CCNL1 ubiquitination

This study identifies CCNL1 as a new substrate of SCF-FBXW7 and shows its role in regulating G2-M progression through ubiquitination, revealing a potential therapeutic target in cancer.

Dynamic control of metabolic zonation and liver repair by endothelial cell Wnt2 and Wnt9b revealed by single cell spatial transcriptomics using Molecular Cartography

This study identifies endothelial cell Wnt2 and Wnt9b as key regulators of liver zonation and repair, showing their therapeutic potential in acute liver failure using single-cell spatial transcriptomics.

Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis

This study identifies SLIT2 as a regulator of metastasis through a genome-wide CRISPR screen of circulating tumor cells in a mouse model.

The Mediator tail module cooperates with proneural factors to determine fate identity in Glioblastoma.

The paper identifies MED24 and MED25 as essential for ASCL1-mediated neuronal differentiation in GSCs and other cell types, revealing a role for the Mediator tail module in this process.

Generation of a New Frizzled 2 Flox Mouse Model to Clarify Its Role in Development

The paper generates a new Fzd2 flox mouse model to investigate tissue-specific roles of Fzd2, resolving contradictions in previous global knockout studies.

Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival

The paper uses single-cell chromatin accessibility to identify distinct glioblastoma stem cell states predictive of patient survival.

The functional genomic circuitry of human glioblastoma stem cells

This study uses CRISPR-Cas9 screens in patient-derived glioblastoma stem cells to identify essential genes and pathways for stemness and drug resistance, revealing new therapeutic targets.