Histidine-Triad Hydrolases Provide Resistance to Peptide-Nucleotide Antibiotics
E. Yagmurov, D. Tsibulskaya, A. Livenskyi, M. Serebryakova, Y. I. Wolf, S. Borukhov, K. V. Severinov, S. Dubiley
The paper identifies histidine triad hydrolases as enzymes conferring resistance to peptide-nucleotide antibiotics like microcin C by hydrolyzing their toxic phosphoramide bond.
bioRxiv · Mar 4, 2020Biochemistry