Author

D. W. Sirkis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

R. Schekman· 2 shared I. Thomas-Wright· 1 shared R. E. Aparicio· 1 shared R. Wade-Martins· 1 shared S. Wu· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 7 mutual co-author links

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2 shared papersBiochemistry

R. Schekman

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2 papers

Recent·Most cited

Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers

S. Wu, D. W. Sirkis, I. Thomas-Wright, R. Wade-Martins, R. Schekman

This study identifies DNAJC5 palmitoylation-mediated oligomerization as a mechanism for α-synuclein unconventional secretion across multiple neuronal cell models.

bioRxiv · Jan 27, 2022Biochemistry

Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment

D. W. Sirkis, R. E. Aparicio, R. Schekman

This study shows that neurodegeneration-associated TREM2 mutants fail to mature and reach the cell surface, accumulating in the ERGIC and suggesting its role in quality control.

bioRxiv · Jun 23, 2017Cell Biology