Peptide inhibitors targeting FOXO4-p53 interactions and inducing senescent cancer cell-specific apoptosis
Donghoon Kang, Yeji Lim, Dabin Ahn, Jaeseok Lee, Chin‐Ju Park
The paper develops a peptide inhibitor targeting FOXO4-p53 interactions to induce apoptosis in senescent cancer cells, showing selectivity and efficacy against chemotherapy-induced senescence.
Journal of Medicinal Chemistry · Jul 31, 2025Peer-reviewedBiochemistry