Enhanced anti-nociception by novel dual antagonists for 5HT2aR and mGluR5 in preclinical models of pain
Daekyu Choi, Hyun Jin Heo, Hae‐Young Shin, Joo Young Im, Geonho Lee, Ah Hyun Kim, Kwang‐Hyun Hur, Yoonmi Nho, Choon‐Gon Jang, Hanmi Lee
This study shows that dual antagonism of 5-HT2AR and mGluR5 enhances anti-nociception in pain models, with efficacy comparable to gabapentin and morphine, but without tolerance or abuse potential.
Biomolecules · Oct 15, 2025Peer-reviewedNeuroscience