Principles of mRNA control by human PUM proteins elucidated from multi-modal experiments and integrative data analysis
Michael B. Wolfe, Trista L. Schagat, Michelle T. Paulsen, Brian Magnuson, Mats E. Ljungman, Daeyoon Park, Chi Zhang, Zachary T. Campbell, Aaron C. Goldstrohm, Peter L. Freddolino
The paper identifies how human PUM proteins regulate gene expression by RNA stability and develops a rulebook to predict functional PREs using machine learning.
RNA · Aug 4, 2020Peer-reviewedMolecular Biology