Brian Magnuson

Characterizing nascent readthrough transcripts in human cells

The paper identifies widespread readthrough transcription in human cells and shows that depletion of specific factors increases its extent.

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Isoform and pathway-specific post-transcriptional RNA processing in human cells

The paper profiles RNA dynamics in 16 human cell lines using Bru-seq and BruChase-seq, showing gene and pathway-specific RNA turnover and isoform regulation.

Characterizing nascent transcription patterns of PROMPTs, eRNAs, and readthrough transcripts in the ENCODE4 deeply profiled cell lines

The paper identifies nascent transcription patterns of PROMPTs, eRNAs, and readthrough transcripts in 16 human cell lines using Bru-seq and finds they are regulated by sequence and chromatin features, suggesting they are functionally important.

Principles of mRNA control by human PUM proteins elucidated from multi-modal experiments and integrative data analysis

The paper identifies how human PUM proteins regulate gene expression by RNA stability and develops a rulebook to predict functional PREs using machine learning.

Replication Timing and Transcription Identifies a Novel Fragility Signature Under Replication Stress

The paper identifies a fragility signature linked to replication stress and transcription in chromosomal instability by analyzing replication timing and gene expression.