Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editing
Dahlia Rohm, Joshua B. Black, Sean R. McCutcheon, Alejandro Barrera, Shanté S. Berry, Daniel J. Morone, Xander Nuttle, Celine E. de Esch, Derek J.C. Tai, Michael E. Talkowski, Nahid Iglesias, Charles A. Gersbach
The paper uses CRISPR-based epigenome editing to activate the silenced maternal SNRPN gene in PWS iPSCs, showing that DNA demethylation can lead to stable expression.
Cell Genomics · Feb 1, 2025Peer-reviewedGenomics