Author

Sean R. McCutcheon

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Charles A. GersbachiD· 3 shared Alejandro BarreraiD· 2 shared Christian D. McRoberts AmadoriD· 2 shared Michael C. BrowniD· 2 shared Adam M. Swartz· 1 shared Aretha R. Gao· 1 shared Celine E. de Esch· 1 shared Dahlia Rohm· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenomics

Charles A. GersbachORCID

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Author profile →

3 papers

Recent·Most cited

RELB Reprograms Exhausted Tumor-Infiltrating Lymphocytes for Improved Adoptive Cell Therapy

Christian D. McRoberts Amador, Rachel E. Conover, Michael C. Brown, Liliana Lyniv, Pamela Noldner, Ying Zhou, Aretha R. Gao, Sean R. McCutcheon, Scott Joseph Antonia, Charles A. Gersbach

This study identifies RELB as a key regulator that enhances TIL expansion and function, improving adoptive cell therapy for solid tumors.

bioRxiv · Oct 11, 2025 · PreprintBioengineering

Activation of the imprinted Prader-Willi Syndrome locus by CRISPR-based epigenome editing

Dahlia Rohm, Joshua B. Black, Sean R. McCutcheon, Alejandro Barrera, Shanté S. Berry, Daniel J. Morone, Xander Nuttle, Celine E. de Esch, Derek J.C. Tai, Michael E. Talkowski, Nahid Iglesias, Charles A. Gersbach

The paper uses CRISPR-based epigenome editing to activate the silenced maternal SNRPN gene in PWS iPSCs, showing that DNA demethylation can lead to stable expression.

Cell Genomics · Feb 1, 2025Peer-reviewedGenomics

Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function

Sean R. McCutcheon, Adam M. Swartz, Michael C. Brown, Alejandro Barrera, Christian McRoberts Amador, Keith Siklenka, Lucas L. Humayun, James M. Isaacs, Timothy E. Reddy, Smita K. Nair, Scott J. Antonia, Charles A. Gersbach

The paper uses CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell function, finding BATF3 as a key gene that enhances memory T cell features and improves CAR T cell therapy outcomes.

bioRxiv · May 1, 2023 · PreprintGenomics