Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka
Yuji Nishiike, Shizuku Maki, Daichi Miyazoe, Kiyoshi Nakasone, Yasuhiro Kamei, Takeshi Todo, Tomoko Ishikawa‐Fujiwara, Kaoru Ohno, Takeshi Usami, Yoshitaka Nagahama, Kataaki Okubo
This study shows brain-derived estrogens enhance male-typical behaviors in medaka by boosting androgen receptor signaling, even though androgens can act directly in other vertebrates.
eLife · Jan 13, 2026Peer-reviewedNeuroscience