Computational analysis reveals the requirement for cell-cell interaction in liver repopulation by transplanted hepatocytes
Daiki Ikuta, Rei Tamaki, Sota Wada, Kotaro Onishi, Masaki Nishikawa, Yasuyuki Sakai, Takeshi Katsuda
The paper uses computational simulations to show that cell-cell interactions are critical for liver repopulation by transplanted hepatocytes, as host hepatocyte death rate dominates repopulation kinetics.
bioRxiv · May 9, 2026 · PreprintSystems Biology