Takeshi Katsuda

The paper uses computational simulations to show that cell-cell interactions are critical for liver repopulation by transplanted hepatocytes, as host hepatocyte death rate dominates repopulation kinetics.

The paper shows H3K9me3 represses lineage-specific enhancers in progenitor cells, restricting transcription factor access to prevent inappropriate activation during development.

This study develops a flow cytometry method to distinguish mononucleated and binucleated tetraploid hepatocytes, revealing that mononucleated cells have more metabolically active gene expression.