Yasuyuki Sakai

Computational analysis reveals the requirement for cell-cell interaction in liver repopulation by transplanted hepatocytes

The paper uses computational simulations to show that cell-cell interactions are critical for liver repopulation by transplanted hepatocytes, as host hepatocyte death rate dominates repopulation kinetics.

A novel sorting method reveals superior metabolic activity of mononucleated over binucleated tetraploid hepatocytes

This study develops a flow cytometry method to distinguish mononucleated and binucleated tetraploid hepatocytes, revealing that mononucleated cells have more metabolically active gene expression.

Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid

This study develops a microfluidic chip model of endochondral ossification using human stem cell-derived organoids, showing vascular-like network formation and interactions.