Unsupervised Ensemble Learning for Efficient Integration of Pre-trained Polygenic Risk Scores
Chenyin Gao, Justin D. Tubbs, Yi Han, Min Guo, Sijia Li, Erica Ma, Dailin Luo, Jordan W. Smoller, Phil H. Lee, Rui Duan
This paper introduces UNSemblePRS, an unsupervised ensemble method for integrating pre-trained polygenic risk scores without phenotype data, showing robust performance across diverse populations.
medRxiv · Jan 6, 2025 · PreprintGenetic & Genomic Medicine