Rui Duan

Real-time dynamic polygenic prediction for streaming data

This paper introduces rtPRS-CS, a real-time polygenic risk score method that dynamically updates predictions as new data streams in, improving accuracy for schizophrenia risk across diverse populations.

A One-Shot Lossless Algorithm for Cross-Cohort Learning in Mixed-Outcomes Analysis

This paper introduces mixWAS, a one-shot, lossless algorithm for integrating distributed EHR datasets to identify cross-cohort genetic associations across multiple outcomes.

Genome-wide association studies in a large Korean cohort identify novel quantitative trait loci for 36 traits and illuminate their genetic architectures

This study conducts GWAS in a large Korean cohort, identifying 301 novel loci and highlighting East Asian-specific genetic associations for 36 traits.

Transdiagnostic Polygenic Risk Models for Psychopathology and Comorbidity: Cross-Ancestry Analysis in the All of Us Research Program

This study evaluates transdiagnostic polygenic risk scores for psychiatric disorders using the All of Us Research Program data, finding that a common psychiatric genetic factor PRS better predicts comorbidity burden than single-disorder scores.

Unsupervised Ensemble Learning for Efficient Integration of Pre-trained Polygenic Risk Scores

This paper introduces UNSemblePRS, an unsupervised ensemble method for integrating pre-trained polygenic risk scores without phenotype data, showing robust performance across diverse populations.

Learning from local to global - an efficient distributed algorithm for modeling time-to-event data

The paper introduces ODAC, a privacy-preserving distributed algorithm for multi-center Cox proportional hazard models, showing it matches pooled estimates and outperforms meta-analysis for rare events.

Evaluation of phenotyping errors on polygenic risk score predictions

This study evaluates how phenotyping errors affect polygenic risk score (PRS) accuracy using eMERGE data, showing accuracy degradation depends on phenotype and error mechanism.