Investigating the therapeutic potential of soluble TREM2 interactions with Transgelin-2 in Alzheimer's disease
David Saeb, Emma E Lietzke, Evan A Wood, Ana F Costa, Emma C Aldrich, Daisy I Fuchs, Ashkon E Chaghajerdi, Kimberley D Bruce, Kayla G Sprenger
This study identifies the structural basis of sTREM2-TG2 interaction in Alzheimer's disease and develops improved peptide modulators based on these findings.
bioRxiv · Nov 2, 2026 · PreprintBioengineering