Kimberley D. Bruce

This study identifies the structural basis of sTREM2-TG2 interaction in Alzheimer's disease and develops improved peptide modulators based on these findings.

This study shows that ApoE4 lipidation state affects human microglial metabolism and function, with lipid-bound ApoE4 causing metabolic reprogramming and lipid-free ApoE4 inducing inflammatory signaling.

This study identifies GPR182 as a lipoprotein receptor that mediates dietary fat absorption and shows its role in obesity resistance.

This study investigates how HSV-1 infection remodels microglial transcriptional and epigenetic states, revealing IFN-responsive dominance and loss of homeostatic signatures in specific brain regions.

The paper validates a method to generate responsive microglia from frozen mixed glial cultures, showing similar functional responses to fresh cultures.

This study uses molecular dynamics simulations and biochemical assays to show that ApoC-II peptide binding stabilizes LPL's structure and regulates its activity through lid flexibility and CTD flipping.

This study identifies the flexible stalk domain of sTREM2 as critical for differential ligand binding and neuroprotection in Alzheimer's disease through molecular dynamics simulations.

This study tracks HSV-1 spread from the nasal passages to the CNS in mice, revealing region-specific infection patterns and microglial responses.

This study investigates age- and sex-related metabolic changes in female brains and microglia, finding that estrogen may suppress disease-associated microglia (DAM) factors, potentially increasing Alzheimer's disease risk in post-menopausal women.