Spatiotemporal Characterization of Amyloidosis-Associated Microglial States Reveals Sex Difference in Early Plaque Formation
Amritha Vinayak Manjally, Abigail Fowler, Jiratchaya Thanayangyuen, Maximillian Cheval, Monica Iordanov, Daisy Liljegren, Yevah Milord, Jonathan Park, Ema Yamashita, Aidan Conley Kieffer, Tuan Leng Tay
This study examines sex differences in microglial responses to amyloid-beta plaques in 5XFAD mice, finding that female mice show increased plaque formation and microglial clustering at 4 months, while males have higher plaque load by 6 months.
bioRxiv · Aug 31, 2026 · PreprintNeuroscience