Author

Tuan Leng Tay

Boston UniversityORCID 0000-0002-3507-6502Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Abigail Fowler· 2 shared Aidan Conley KiefferiD· 2 shared Amritha Vinayak Manjally· 2 shared A.B. Vega LópeziD· 1 shared André FischeriD· 1 shared Andre Krunic· 1 shared Anish Krishna· 1 shared Aoife Kateri O’ConnelliD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Abigail Fowler

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatiotemporal Characterization of Amyloidosis-Associated Microglial States Reveals Sex Difference in Early Plaque Formation

Amritha Vinayak Manjally, Abigail Fowler, Jiratchaya Thanayangyuen, Maximillian Cheval, Monica Iordanov, Daisy Liljegren, Yevah Milord, Jonathan Park, Ema Yamashita, Aidan Conley Kieffer, Tuan Leng Tay

This study examines sex differences in microglial responses to amyloid-beta plaques in 5XFAD mice, finding that female mice show increased plaque formation and microglial clustering at 4 months, while males have higher plaque load by 6 months.

bioRxiv · Aug 31, 2026 · PreprintNeuroscience

Reproducible transversal mouse brain sections using low-cost 3D printable resin matrix

Kelly Falcón, A.B. Vega López, Rita Thammakhoune, Hope Ayim, Matthew Clark Jung, Anish Krishna, Camila C. Aragón, Aidan Conley Kieffer, Tuan Leng Tay

This paper introduces a low-cost 3D-printed resin matrix for generating reproducible transversal mouse brain sections, comparable to commercial matrices.

bioRxiv · Jul 30, 2026 · PreprintNeuroscience

MicroRNA-223 Enhances Microglia-Dependent Clearance of Amyloid Beta Plaques and Ameliorates Behavioral Deficits in a Mouse Model of Alzheimer's Disease

Andre Krunic, Nikkitha Umesh Ganesh, Ugur Coskun, William Brennan, Patel Cd, Ojasi Joshi, Jane Lee, Tori Shiyang Gu, Jaclyn Caruso, Aoife Kateri O’Connell, Charles Lisboa, Nicholas A. Crossland, Margareta Kurkela, Julia TCW, Abigail Fowler, , Tiffany J. Mellott

This study shows that miR-223 improves cognitive function and reduces amyloid beta plaques in an Alzheimer's mouse model by enhancing microglial clearance.

bioRxiv · Jul 23, 2026 · PreprintNeuroscience

AutoMorFi: Automated Whole-image Morphometry in Fiji/ImageJ for Diverse Analyses and Discoveries

Ouzéna Bouadi, Chenkai Yao, Jason Zeng, Danielle Beason, Nyomi Inda, Zoe Malone, Jonathan Yoshihara, Amritha Vinayak Manjally, Clifton Johnson, Jonathan D. Cherry, Chin‐Yi Chen, Tzu-Chieh Huang, B. Popović, Maria Henley, Guangmei Liu, , Tuan Leng Tay

AutoMorFi automates whole-image morphometric analysis, generating over 47 measurements per cell quickly and enabling new discoveries across diverse biological samples.

bioRxiv · Jul 26, 2024 · PreprintCell Biology