Aggregated Low-Density Lipoprotein (agLDL) Triggers Inflammatory Responses in Macrophages through Toll-Like Receptor 4 (TLR4)
Samia Kadri, Zeina Salloum, Judy Zhen, Cheng-I Jonathan Ma, Dajiang Zhang, Thomas A. Lagace, Frederick R. Maxfield, Xiaohui Zha
This study shows aggregated LDL (agLDL) activates TLR4 in macrophages, triggering inflammation and contributing to atherosclerosis through the NF-κB pathway.
bioRxiv · Sep 28, 2026 · PreprintCell Biology