Frederick R. Maxfield

This study shows aggregated LDL (agLDL) activates TLR4 in macrophages, triggering inflammation and contributing to atherosclerosis through the NF-κB pathway.

The paper uses ApHID-dextran to measure lysosomal pH in mouse meningeal phagocytes, revealing incomplete acidification and changes under pathological conditions.

The paper introduces a novel pH-sensitive probe, ApHID, for real-time ratiometric pH imaging of macrophage lysosomes, showing improved performance over existing probes.

This study shows FGF13 modulates VGSCs by regulating membrane cholesterol, independent of direct channel binding, and reveals its role in maintaining cholesterol distribution and VGSC localization at the intercalated disc.

This paper develops a high-content microscopy drug screening platform to identify compounds that inhibit lysosome exocytosis during digestive exophagy in macrophages.

The paper identifies small molecule compounds that reduce cholesterol accumulation in human NPC1 mutant fibroblasts but not in NPC1-/- cells, suggesting on-target effects.

This study identifies dysregulation of cholesterol and matrisome pathways in human APOE ε4 glia, linking them to Alzheimer's disease risk.