Author

Thomas A. Lagace

Ottawa Heart InstituteORCID 0000-0002-6946-4212Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander C. Y. FooiD· 1 shared Angela Matyas· 1 shared Ariela Vergara‐JaqueiD· 1 shared Cheng-I Jonathan MaiD· 1 shared Dajiang Zhang· 1 shared Frederick R. MaxfieldiD· 1 shared Ikhuosho Asikhia· 1 shared Judy Zhen· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Alexander C. Y. FooORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 28, 2026

Aggregated Low-Density Lipoprotein (agLDL) Triggers Inflammatory Responses in Macrophages through Toll-Like Receptor 4 (TLR4)

Samia Kadri, Zeina Salloum, Judy Zhen…·Xiaohui Zha

This study shows aggregated LDL (agLDL) activates TLR4 in macrophages, triggering inflammation and contributing to atherosclerosis through the NF-κB pathway.

DOI 10.64898/2026.09.24.754244

humanbulk RNA-seq

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Molecular BiologyJournal of Biological ChemistryPeer-reviewedJan 16, 2020

A transient amphipathic helix in the PCSK9 prodomain facilitates low-density lipoprotein binding

Samantha K. Sarkar, Alexander C. Y. Foo, Angela Matyas…·Thomas A. Lagace

This study identifies a transient amphipathic helix in PCSK9's prodomain that facilitates LDL binding, with mutations affecting this structure altering binding affinity and activity.

26 citations

humanproteomics

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