Neoadjuvant chemotherapy induces transient, regimen-specific immune stromal reprogramming in pancreatic ductal adenocarcinoma
Elahe Minaei, Dezerae Cox, Amarinder Singh Thind, Gary Tincknell, Leo A. Coleman, Samantha J. Wade, Naila Islam, Dale Waring, Mona Ahuja, Joanne La Malfa, Koroush Shahsavar Haghighi, Marie Ranson, Morteza Aghmesheh, Ronald Sluyter, Eileen Mary O'Reilly, Kara L. Vine
This study shows that neoadjuvant chemotherapy temporarily changes the immune and stromal environment in pancreatic cancer based on the treatment regimen and timing.
bioRxiv · Sep 11, 2026 · PreprintCancer Biology