Eileen Mary O'Reilly

Systemic iron sequestration restricts the intratumoral CD8+ T cell landscape in pancreas cancer

This study shows that systemic iron sequestration via hepcidin reduces CD8+ T cells in pancreas cancer, linking iron dysregulation to tumoral immunity.

Neoantigen-reactive CD8+ T cell engagement marks exceptional survivors of pancreatic cancer

The paper identifies TIE CD8+ T cell clonotypes associated with prolonged survival in pancreatic cancer patients and links resistance to stromal and immune barriers.

Neoadjuvant chemotherapy induces transient, regimen-specific immune stromal reprogramming in pancreatic ductal adenocarcinoma

This study shows that neoadjuvant chemotherapy temporarily changes the immune and stromal environment in pancreatic cancer based on the treatment regimen and timing.

POLQ-driven repair scars shape the immunogenic landscape of homologous recombination-deficient pancreatic cancer

The paper identifies MDF, a repair scar linked to POLQ-driven error-prone repair, as a marker of immune-responsive HRD pancreatic cancer with increased neoantigens and favorable clinical outcomes.

Genomic evolution of pancreatic cancer at single-cell resolution

This study uses single-nucleus DNA sequencing to analyze pancreatic cancer evolution, revealing patterns of mutation and copy number variation across clinical scenarios.

Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer

The paper analyzes transcriptomic changes in metastatic pancreatic cancer using a patient's autopsy data to identify site-specific gene programs and clonal phylogeny.

Enhanced specificity of high sensitivity somatic variant profiling in cell-free DNA via paired normal sequencing: design, validation, and clinical experience of the MSK-ACCESS liquid biopsy assay

The paper describes the development and clinical application of MSK-ACCESS, a liquid biopsy assay that improves the specificity of somatic variant detection in cell-free DNA by using paired normal sequencing.