Dezerae Cox

Streptococcus pyogenes transforms the salivary proteome during controlled human infection

This study identifies changes in the salivary proteome during Streptococcus pyogenes infection, revealing inflammatory responses and virulence factor interactions.

Neoadjuvant chemotherapy induces transient, regimen-specific immune stromal reprogramming in pancreatic ductal adenocarcinoma

This study shows that neoadjuvant chemotherapy temporarily changes the immune and stromal environment in pancreatic cancer based on the treatment regimen and timing.

Direct single-molecule visualization of Hsp90-mediated relief of a Hsp70-folding block

This study uses single-molecule techniques to show how Hsp90 helps Hsp70 release folding intermediates and remodel client proteins to enable proper refolding.

Differential inclusion formation of an aggregation-prone protein reveals differences in the proteostasis capacity of neuronal cell lines

The paper compares proteostasis capacity in two neuronal cell lines by analyzing inclusion formation of an aggregation-prone protein, revealing differences in proteostasis machinery engagement.

Small tau aggregates exhibit disease-specific molecular profiles across tauopathies

The paper identifies disease-specific molecular profiles of small tau aggregates across different tauopathies using single-molecule assays.

Lipid-Coated Water-in-Oil Droplets as a Passivation-Free Platform for Cost-Effective Fluorescence Spectroscopy

This paper introduces a passivation-free platform using lipid-coated water-in-oil droplets for fluorescence spectroscopy, enabling accurate measurements of molecular dynamics in nanolitre volumes.

Single-molecule observations of human small heat shock proteins in complex with aggregation-prone client proteins

This study uses single-molecule techniques to characterize how human sHsps bind to aggregation-prone client proteins and form complexes.

Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease

This study uses single molecule microscopy to fingerprint TDP-43 aggregates in brain tissue, distinguishing MND donors from controls and different MND cohorts.