Design of TCR-mimicking binders for pHLA with high potency
Teng Xie, Yaqi Fu, Shi-Meng Gong, Damiano Burrato, Ruhong Zhou
The paper designs high-specificity binders for pHLA complexes using a deep learning and simulation framework, achieving nanomolar potency and mutation selectivity.
bioRxiv · Oct 3, 2025 · PreprintBiophysics