Co-expression of MDM2 and CDK4 in transformed human mesenchymal stem cells induces dedifferentiated liposarcoma potency
Yu Jin Kim, Minjung Sung, Dan Bi Yu, Mingi Kim, Ji-Young Song, Kyoung Song, Kyungsoo Jung, Yoon-La Choi
This study shows that co-overexpression of MDM2 and CDK4 in transformed human BMSCs leads to dedifferentiated liposarcoma-like tumorigenesis by enhancing cell growth and migration while inhibiting adipogenic differentiation.
bioRxiv · Apr 1, 2018 · PreprintCancer Biology